Phase I study on a new prostacyclin derivative E-1030 (I loprost).
نویسندگان
چکیده
منابع مشابه
A phase I and pharmacokinetic study of a new camptothecin derivative, 9-aminocamptothecin.
Camptothecins are the only available antitumor agents which target the nuclear enzyme topoisomerase I. 9-Aminocamptothecin (9-AC) is a water-insoluble derivative of camptothecin which has demonstrated impressive antitumor activity in preclinical models. While two other water-soluble derivatives, CPT-11 and topotecan, have successfully completed Phase I and Phase II testing, biochemical and tiss...
متن کاملTrain Scheduling Problem - Phase I: A General Simulation Modeling Framework
One of the important problems in management of railway systems is train scheduling problem. This is the problem of determining a timetable for a set of trains that do not violate infrastructure capacities and satisfies some operational constraints. In this study, a feasible timetable generator framework for stochastic simulation modeling is developed. The objective is to obtain a feasible tr...
متن کاملSerum prostacyclin stabilizing factor is identical to apolipoprotein A-I (Apo A-I). A novel function of Apo A-I.
Serum PGI2 stabilizing factor (PSF) was purified from human serum to a single protein with a molecular weight of 28,000 D by SDS-PAGE. Analyses of NH2-terminal sequence (32 residues), COOH-terminal sequence (3 residues) and the composition of amino acids disclosed its homology with human apolipoprotein A-I (Apo A-I), a major apolipoprotein of HDL. Apolipoprotein A-II, C-I, C-II, C-III, D and E,...
متن کاملNEW INFORMATION ON THE FORM-GENUS CYTOSPORA IN IRAN (I)
In order to study of the form-genus Cytospora, around 400 specimens were collected from all over the Iran during 2003-2005. In this paper, the first part of the obtained results, including seven form-species are presented. Cytospora atrocirrhata, C. carbonacea, C. gutnerae, C. nivea and C. rosarum are reported as new members for mycoflora of Iran. Also, Vitis vinifera for C. leucostoma and Celt...
متن کاملI-31: New Approaches for Luteal Phase Support in ART Cycles
Background During a normal menstrual cycle, progesterone prepares the endometrium for pregnancy by stimulating proliferation in response to human chorionic Gnadotropin produced by the corpus luteum. Many questions were raised about the role of follicular fluid aspiration on the granuloma cells at the time of oocyte retrieving during the ART cycles. Authors believes that oocyte retrieval might d...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics
سال: 1988
ISSN: 1882-8272,0388-1601
DOI: 10.3999/jscpt.19.283